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Anabolic Steroids & Diabetes A hindered ability to process insulin can be one outcome in the cascade of effects precipitated by anabolic steroids(ASTs). While the mechanism by which anabolic steroids impact diabetes remains unclear, it has been suggested that they enhance insulin sensitivity [1,3]. Evidence on the association between insulin sensitivity and the pharmacokinetics of anabolic steroids appears conflicting. Recent reports on the role of anabolic steroids in the etiology of diabetes include a series of studies by Akerlof and colleagues based on a retrospective study which demonstrated that acute administration of dexmethylsulfonyl fluoride of 7.25 mg/kg was associated with higher insulin levels at 48 h in subjects with Type 2 diabetes compared to persons with no reported prediabetes [3]. In this same study, chronic doses of dihydrofluoromethyl-lactate of 500 mg/kg (a higher concentration than in the case of the previous study) were associated with insulin resistance at 24 h following acute administration in patients with Type 2 diabetes [11]. A second study demonstrated that 3 days of dexmethylsulfonyl fluoride was more effective than intravenous insulin at lowering serum concentrations of both glycerol and glucose, the levels at which insulin action occurred [9]. The study by Al-Fazak et al. (2013) [5] reported the development of insulin resistance in insulin-resistant subjects receiving 100-2000 IU/day of d-amphetamine or a placebo in the presence of oral administration of either placebo or 200 mg/kg of dexmethylsulfonyl fluoride of 7.25 mg/kg. The authors noted that after 40 days of treatment, the increase in serum glucose and C-peptide was similar to the placebo group. No differences in insulin resistance or insulin secretion were reported at the end of 42 days during which time the subjects were receiving d-amphetamine and placebo. This finding may be explained by the use of a different formulation or the presence or absence of a high-fat diet due to the influence of d-amphetamine (which is devoid of fat). A third study showed that d-amphetamine was effective in decreasing both fasting and postprandial serum glucagon levels in subjects with insulin resistance due to glucose intolerance [5]. In addition to increasing blood glucose concentration, anabolic steroids increase fasting blood glucose levels, which may contribute to insulin resistance in insulin-sensitive individuals. Another study, by Li et al. [8] compared subjects treated with 1-month d-amphetamine with subjects treated with placebo in a double-blind crossover design. Two groups of subjects received 1% of their energy from ananaxole or
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